Ardmore is a train station in Ardmore, Oklahoma, United States. It is served by Amtrak's Heartland Flyer train. It is located downtown at 251 East Main Street, and is fully wheelchair accessible. Passengers are not allowed in the depot building as it houses the offices of Downtown Main Street.The station was built by the Atchison, Topeka and Santa Fe Railway in 1916, replacing a 1909-built station which had been destroyed by an explosion.